The article presents a correlation analysis between hemodynamic changes occurred after performing submaximum physical activity using bicycle ergometer (physical stress) and intravenous injection of adrenalin (pharmacological stress) in 30 liquidators of Chernobyl accident and who have a neurocirculatory dystonia syndrome. It enables to establish interrelations for a number of maximal values of parameters of hemodynamics which is determined by the same shifts in circulatory system with sympathoadrenal direction during these two kinds of stress influence.
Epinephrine/administration & dosage , Exercise/physiology , Hemodynamics/physiology , Neurocirculatory Asthenia , Occupational Diseases , Sympathomimetics/administration & dosage , Adult , Chernobyl Nuclear Accident , Exercise Test , Hemodynamics/drug effects , Humans , Infusions, Intravenous , Male , Middle Aged , Neurocirculatory Asthenia/etiology , Neurocirculatory Asthenia/physiopathology , Occupational Diseases/etiology , Occupational Diseases/physiopathology , Syndrome , Ukraine
The author established distinctive sex and age differences in tonus state of arterial little and medium size vessels located in the brain hemispheres in patients with arterial hypertension, which have suffered from Chernobyl accident, using tetrapolar impedance plethysmography (RA5-01).
Brain/blood supply , Brain/radiation effects , Chernobyl Nuclear Accident , Hypertension/physiopathology , Muscle Tonus/radiation effects , Muscle, Smooth, Vascular/radiation effects , Adult , Age Factors , Arteries/radiation effects , Female , Humans , Hypertension/etiology , Male , Middle Aged , Plethysmography, Impedance , Sex Factors
The study have been conducted using a tetrapolar impedance plethysmography technique (RA5-01 rheoanalyser). Reliable differences of some amplitude-time rheogram parameters of cerebral hemispheres and shins in hypertensive patients with vegetative dysfunctions manifested somatically and who had suffered from harmful consequences of Chernobyl accident have been established.
Autonomic Nervous System Diseases/physiopathology , Chernobyl Nuclear Accident , Hypertension/physiopathology , Adult , Autonomic Nervous System Diseases/complications , Blood Flow Velocity/physiology , Cerebral Cortex/blood supply , Cerebrovascular Circulation/physiology , Humans , Hypertension/complications , Leg/blood supply , Plethysmography , Regional Blood Flow/physiology , Time Factors
Reliable differences in cerebral hemisphere blood vessels filling and tonus of microcirculation system have been found between men and women of different ages with arterial hypertension, who have suffered from Chernobyl accident with the help of tetrapolar impedance plethysmography method (rheoanalysator PAS-01). Cerebral hemisphere blood vessels filling in women of all ages has been shown to be higher for sure than in men and the tonus of pre- and postcapillaries under developing arterial hypertension gets lower with age.
Aging/radiation effects , Brain , Cerebral Veins/radiation effects , Cerebrovascular Circulation/radiation effects , Chernobyl Nuclear Accident , Hypertension/physiopathology , Adult , Brain/blood supply , Brain/physiopathology , Brain/radiation effects , Cerebral Veins/physiopathology , Female , Humans , Hypertension/etiology , Male , Middle Aged , Plethysmography, Impedance , Sex Factors , Ukraine
Reliable difference of microvascular filling and microvascular tone of cerebral hemispheres and shins according to impedance tetrapolar plethysmography (rheoanalyzer PAS-01) data in patients with vegetovascular dystonia and arterial hypertension, suffered from Chernobyl accident was detected.
Autonomic Nervous System Diseases/physiopathology , Blood Volume/physiology , Chernobyl Nuclear Accident , Dystonia/physiopathology , Hypertension/physiopathology , Vascular Resistance/physiology , Adult , Autonomic Nervous System Diseases/etiology , Blood Volume/radiation effects , Dystonia/etiology , Female , Humans , Hypertension/etiology , Male , Microcirculation/physiology , Microcirculation/radiation effects , Middle Aged , Ukraine , Vascular Resistance/radiation effects
Clear-cut distinction in blood vascular filling and vascular tone of arterial vessels of the cerebral hemisphere and shanks in patients suffered from Chernobyl accident and with arterial hypertension and vegetative dysfunction manifested somatically has been detected by means of impedance tetrapolar plethysmography (rheoanalyzer RA5-01).
Arteries/physiopathology , Autonomic Nervous System Diseases/physiopathology , Blood Volume/physiology , Chernobyl Nuclear Accident , Hypertension/physiopathology , Muscle Tonus/physiology , Adult , Angiography , Arteries/radiation effects , Blood Volume/radiation effects , Brain/blood supply , Electroencephalography , Female , Hemodynamics/physiology , Humans , Leg/blood supply , Male , Middle Aged , Muscle Tonus/radiation effects , Muscle, Smooth, Vascular/physiopathology , Muscle, Smooth, Vascular/radiation effects , Plethysmography, Impedance , Ukraine
Reliable differences in venous drainage and venous congestion and blood vessels filling of cerebral hemispheres in patients with vegetovascular dystonic and arterial hypertention who have suffered from Chernobyl accident have been detected by means of impedance tetrapolar plethysmography (rheoanalyzer PA5-01).
Autonomic Nervous System Diseases/physiopathology , Blood Volume/physiology , Chernobyl Nuclear Accident , Hypertension/physiopathology , Vascular Resistance/physiology , Veins/physiology , Adult , Angiography , Autonomic Nervous System Diseases/etiology , Blood Volume/radiation effects , Cerebrovascular Circulation/physiology , Cerebrovascular Circulation/radiation effects , Dystonia/etiology , Dystonia/physiopathology , Electroencephalography , Female , Humans , Hypertension/etiology , Leg/blood supply , Male , Muscle, Smooth, Vascular/physiopathology , Muscle, Smooth, Vascular/radiation effects , Plethysmography, Impedance , Ukraine , Vascular Resistance/radiation effects , Veins/radiation effects
Glycine injection to the identified area of the RVLM leads to the development of a characteristic depressor reaction, due to a decrease of the total peripheral vascular resistance (TRP). Glycine injection to the identified area of CVLM results in the developing pressor reaction also due to the changes of TRP. Glycine injection to CVLM under preliminary functional switch-off the RVLM neuronal activity is not accompanied by the development of pressor reaction. This can be an evidence that CVLM sympathoinhibitory neurones act on cardiohemodynamics by their interaction with RVLM sympathoexcitatory neurones. Turn off of the tonically active sympathoinhibitory CVLM neurones does not affect the character of the reactions depending on the inhibition or excitation of sympathoexcitatory RVLM neurones.
Cardiovascular System/innervation , Hemodynamics/physiology , Medulla Oblongata/cytology , Myocardial Contraction/physiology , Neurons/physiology , Vasomotor System/physiology , Animals , Cats , Glycine/pharmacology , Hemodynamics/drug effects , Myocardial Contraction/drug effects , Neural Inhibition/drug effects , Neural Inhibition/physiology , Neural Pathways/drug effects , Neural Pathways/physiology , Neurons/drug effects , Vasomotor System/drug effects
Inhibition of the separate neuronal groups located in the caudal ventrolateral part of the cat medulla at different depths from the brain surface is followed by the development of unidirectional cardiohemodynamic reactions. Microinjection of 30 nl of 0.1 M solution of glycine in the chemosensitive area "L" at a depth not more than 700 microns is followed by an increase of the arterial pressure to 160-225%, presumably, due to enhancement of the total peripheral vascular resistance, the cardiac output and heart rate change insignificantly. Such direction of hemodynamic changes is due to activation of the neurogenic vascular tone. Data obtained give the possibility to appreciate investigated neuronal groups as tonically active, with an inhibitory influence on sympathetically activation of the vessels. The method of the retrograde axonal transport of HRP was used to determine monosynaptic projections from different neuronal pools of the caudal ventrolateral part of medulla to the subsolitary district of the reticular formation. The data obtained contribute to comprehension of mechanisms of interaction in the dorsal and ventral areas of the medulla participating in the regulation of the vascular tone.
Medulla Oblongata/physiology , Neurons/physiology , Vascular Resistance/physiology , Animals , Axonal Transport/drug effects , Cats , Glycine/pharmacology , Heart/drug effects , Heart/physiology , Hemodynamics/drug effects , Hemodynamics/physiology , Horseradish Peroxidase , Medulla Oblongata/drug effects , Microinjections , Neural Inhibition/drug effects , Neural Inhibition/physiology , Neurons/drug effects , Vascular Resistance/drug effects